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Immunity Genes May Play a Role in Down Syndrome
Immunity Genes May Play a Role in Down Syndrome
Extra copies of four interferon receptor genes found on human chromosome 21 trigger developmental changes in a mouse model of Down syndrome.
Extra copies of four interferon receptor genes found on human chromosome 21 trigger developmental changes in a mouse model of Down syndrome.
signaling pathways
Mice With a Healthy Gut Microbiome Are More Motivated to Exercise
Katherine Irving | Dec 16, 2022 | 4 min read
A neural pathway between the gut and the brain led to the release of dopamine when the mice ran on a wheel or treadmill, but only in the presence of a robust microbiome.
Retching Mice Reveal the Brain Circuit Behind Vomiting
Katherine Irving | Nov 2, 2022 | 2 min read
The discovery could one day lead to the development of better antinausea medications.
Cross-Resistance: One Cancer Therapy Can Undermine the Next
Sophie Fessl, PhD | Jul 16, 2021 | 6 min read
Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.
High Stress Hormone Levels Halt Mouse Fur Growth
Jef Akst | Apr 1, 2021 | 4 min read
Corticosterone interferes with signaling in the skin that normally activates hair follicle stem cells, possibly explaining the link between stress and hair loss.
Developmental Biologist Kathryn Anderson Dies at 68
Amanda Heidt | Jan 6, 2021 | 4 min read
The Sloan Kettering researcher used mutagenic screening to probe genes and molecular pathways, including Toll and Hedgehog, essential to development in fruit flies and mice.
The Structure and Functions of the p53 Pathway: Information Acquisition, Redundancy, and Connectivity
The Scientist’s Creative Services Team | Jun 5, 2020 | 1 min read
Arnold Levine will discuss his discovery of p53 and the evolution of the field since then, and Jon Chen will discuss the use of single-cell phosphoproteomics in identifying changes in key signaling networks, including p53.
Compounds from Smoke Alter Root Development in Plants
Shawna Williams | Mar 1, 2020 | 2 min read
Defects in the response to fire-generated karrikins turn out to be responsible for root anomalies that were previously ascribed to other plant hormones.
Into the Light: A Profile of Joanne Chory
Emily Makowski | Mar 1, 2020 | 8 min read
The plant geneticist has revolutionized researchers’ understanding of how light affects plant growth and development, and is engineering plants to combat climate change.
Pufferfish Spines Shaped by Same Genes as Feathers and Fish Scales
Nicoletta Lanese | Jul 29, 2019 | 3 min read
To see if the spiky fish shares signaling pathways found in other organisms, scientists scooped up specimens during a mating frenzy on the shores of Japan.
Bacterial Cell Envelope Size is Key to Membrane Stress Response
Diana Kwon | Mar 1, 2018 | 2 min read
Transmission of stress signals in E. coli is dependent on the distance between its inner and outer membranes.
Your Body Is Teeming with Weed Receptors
Megan Scudellari | Jul 16, 2017 | 10+ min read
And the same endocannabinoid system that translates marijuana's buzz-inducing compounds into a high plays crucial roles in health and disease outside the brain.
Endocannabinoids in the Groove
Megan Scudellari | Jul 16, 2017 | 2 min read
The system responsible for the buzz humans get from marijuana plays a passel of physiological roles outside the brain.
Professional Marksman
Anna Azvolinsky | Apr 1, 2015 | 8 min read
Charles Sawyers, who began his research career just as the genetic details of human oncogenes were emerging, codeveloped Gleevec, the quintessential targeted cancer therapy.