reprogramming

Scientists discover how to convert the brain’s glial cells into multipotent neural stem cells.

Various microbes, including several human pathogens, hijack the cell’s skeleton, membranes, and protein-making machinery to make themselves at home.

When implanted into mice, the “pseudo-islets” helped treat the animals’ diabetes symptoms.

The researcher stole genetically modified seeds and planned to give them to a crop research institute in China, the US Justice Department says.

Activating genes for reprogramming factors for a short time transforms large numbers of differentiated cells into multipotent forms that could be useful for cell-based therapies.

By converting glial cells into dopaminergic neurons, scientists were able to partially rescue motor behavior in mice.

Since their introduction to the lab, pluripotent stem cells have gone from research tool to therapeutic, but the journey has been rocky.

Murine embryos undergoing first cell division can reprogram injected sperm and develop normally. 

Researchers use the CRISPR/Cas system to express three transcription-factor genes, changing the identities of mouse cells.

Researchers reprogram human skin cells to make insulin-producing pancreatic cells that can prevent diabetes in mice.

A tour of efforts to automate the production and differentiation of induced pluripotent stem cells

Human induced pluripotent stem cells appear functionally equivalent to stem cells from embryos in a study.

Scientists present new recipes for directly converting glial cells to neurons in mouse brains.

Two research groups have devised small-molecule recipes to directly transform fibroblasts into neurons.

Among the first to discover epigenetic reprogramming during mammalian development, Wolf Reik has been studying the dynamics of the epigenome for 30 years.

The animal world is full of clever solutions to bioengineering challenges.

From artificial chromosomes to mind-controlled gene expression, scientists pushed the boundaries of manipulating biology this year.

RIKEN’s Haruko Obokata fails to replicate stimulus-triggered acquisition of pluripotency.

Can mechanical forces alone be manipulated to create stem-like cells?