melanoma

In mice, the tumor cells are able to thwart the immune response that would kill them—but immunotherapy prevented the return of melanoma.

Glowing cells mark the routes of tumor spread by way of newly formed lymph vessels. 

A new approach to immunotherapy finds that the immune-cell clonotypes that come to the rescue start out at very low frequencies.

Through similar mechanisms, amino acid depletion in culture and cytokine activity in the tumor microenvironment prompt cancer cells to metastasize.

See what cytokine activity and cellular starvation have to do with cancer metastasis.

Early-stage melanoma cells alter proteins in nearby skin cells to create a favorable environment for cancer progression.

People without red hair who possess the variant are also more likely to develop this form of skin cancer, researchers report.

Instructor, Department of Systems Biology, University of Texas MD Anderson Cancer Center. Age: 38

Researchers have developed a technique to visualize the origin of melanoma in zebrafish, throwing light on a genetic switch for cancer.

Mice given a dietary supplement had faster-progressing melanoma, a study shows.

Two compounds boost the ability of melanoma cells to invade other tissues in mice, providing additional evidence that antioxidants can be beneficial to malignant cells as well as healthy ones.

Phase 3 data from a clinical trial show a positive response to a melanoma treatment based on a modified herpesvirus.

T-cell receptor repertoires could help researchers determine whether a certain treatment will work for a given cancer patient. 

A dendritic cell vaccine targeting melanoma patients’ tumor-specific mutations can activate a broad range of cancer-fighting T cells. 

Researchers uncover a previously unknown way UV light can act on melanin, spurring cancer-causing mutations hours after sun exposure.

Researchers identify a unique chemical signature associated with human melanoma cells that could lead to new ways to screen for the disease.
 

The majority of human melanomas contain mutations in a gene promoter, suggesting mutations in regulatory regions may spur some cancers.

Researchers identify an unexpected molecular explanation for the higher incidence of skin cancer in redheads.

Vesicles released by melanoma cells stimulate pro-metastasis behaviors in bone marrow cells.

Starvation paired with cancer drugs slowed or stopped unchecked cell growth in yeast and mouse models of cancer, outpacing or matching the isolated effects of chemo.