Femur tissue from mouse treated with saline (left) and a mouse treated with protein from the larger family of transmembrane glycoproteins (right) 10 days after exposure to radiation. Tissue stained using hematoxylin and eosin (H&E) to visualize the hematopoietic bone marrow microenvironment. Scale bar is 50 μm.
CHRISTINA M. TERMINI/UNIVERSITY OF CALIFORNIA LOS ANGELES, DEPT. OF MEDICINE, HEMATOLOGY/ONCOLOGY
John Chute’s lab at the University of California, Los Angeles, studies how specific proteins regulate the recovery of hematopoietic stem cells and the microenvironment after bone marrow activity is decreased due to radiation. In a recent experiment, Christina Termini and colleagues administered recombinant proteins from the family of transmembrane glycoproteins to mice after whole body irradiation. Their preliminary result suggests that the protein treatment enhanced hematopoietic recovery.
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