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Tumor microenvironment concept with cancer cells
Cancers Protect Themselves Against Their Own Mutations
Tumors overexpress certain genes to survive a growing pile of harmful mutations, a trait that scientists could exploit to target with drugs.
Cancers Protect Themselves Against Their Own Mutations
Cancers Protect Themselves Against Their Own Mutations

Tumors overexpress certain genes to survive a growing pile of harmful mutations, a trait that scientists could exploit to target with drugs.

Tumors overexpress certain genes to survive a growing pile of harmful mutations, a trait that scientists could exploit to target with drugs.

gene expression

Professor Alexandra Whiteley and graduate student Autumn Matthews look at an image of a western blot on their laboratory computer.
An Ancient Viral Protein May Play a Key Role in ALS
Aditi Subramaniam, PhD | Aug 15, 2023 | 4 min read
Researchers find that UBQLN2 gene dysfunction causes a virus-like protein to accumulate in cells, which changes gene expression and may contribute to disease progression in amyotrophic lateral sclerosis (ALS).
Composition of DNA with a glitch effect
“Silent” Mutations Make Noise In Cancer
Katarina Zimmer | May 1, 2023 | 10+ min read
Synonymous mutations have long been ignored in cancer studies since they don’t affect the amino acid sequences of proteins. But research increasingly reveals that they can have disease-driving effects.
Sartorius
Understanding the Blood Cancer Genomic Landscape 
The Scientist’s Creative Services Team | 1 min read
Information about the genomic and immunological characteristics of blood cancers is helping scientists discover and develop new immunotherapies.
Histology showing IL-6 expression
Immune Molecule Alters Cellular Makeup of Human Brain Organoids
Charles Q. Choi, Spectrum | Apr 17, 2023 | 4 min read
The changes may help explain the link between maternal infection and autism, though more research is needed.
Artist’s rendition of orange DNA coiled around a blue histone protein.
“Cryptic Transcription”: How Aging Cells Express Fragments of Genes
Kamal Nahas, PhD | Apr 6, 2023 | 4 min read
Aging cells with weakened gene regulation spuriously transcribe RNAs, but their impact on health and longevity still needs to be examined.
VAI
One Sequence, Many Variations
Van Andel Institute | 5 min read
Andrew Pospisilik explores the epigenetic changes that give organisms the plasticity to change in response to their environments.
Headshots of three people smiling and looking at camera.
2023 Brain Prize Awarded for Research on Synaptic Plasticity
Natalia Mesa, PhD | Mar 23, 2023 | 3 min read
The Lundbeck Foundation announces an international cohort of neuroscientists have collectively won the €1.3 million Brain Prize.
The face of a young woman and the face of an old man surrounded by mechanical clocks.
Daily Gene Expression Rhythms Vary with Sex and Age: Study
Alejandra Manjarrez, PhD | Feb 2, 2023 | 3 min read
By studying tissues from deceased people, a team found that women have more rhythmical gene expression and that this molecular rhythmicity decreases with age.
VAI
Exposed: Environmental Echoes in Health - A Special Podcast Series
The Scientist’s Creative Services Team and Van Andel Institute | 2 min read
Epigenetic experts discuss how environment and diet leave lasting impressions on the human genome.
Illustration of DNA double helix with purple background.
Unbalanced Allele Expression Associated with Mutation, Disease
Natalia Mesa, PhD | Feb 2, 2023 | 5 min read
A study identifies nearly 3,000 genes where one allele tends to be expressed more than the other, but the findings ignited controversy in the field. 
Coronal section of a brain
Immunity-Linked Genes Expressed Differently in Brains of Autistic People
Laura Dattaro, Spectrum | Jan 11, 2023 | 4 min read
Data from postmortem brain tissues adds to the evidence that inflammation is associated with autism.
Discover how to Select and Design qPCR Probes
Selecting Probes That Rise to Any qPCR Challenge
The Scientist’s Creative Services Team and LGC Biosearch Technologies | 1 min read
Learn how to select qPCR probes that match downstream applications.
2022 Top 10 Innovations 
2022 Top 10 Innovations
The Scientist Staff | Dec 12, 2022 | 10+ min read
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
Cells with miRNA activity reporter glowing
MicroRNAs Can Boost Gene Expression: Study
Holly Barker, PhD | Nov 15, 2022 | 3 min read
The tiny strings of RNA promote translation of a protein implicated in cancer, a hint they could regulate gene expression in more ways than previously thought.
Smarter Sample Prep for Improved Single-Cell Sequencing
Smarter Sample Prep for Single-Cell Sequencing
The Scientist’s Creative Services Team and Miltenyi Biotec | 1 min read
In this webinar, Carina Emery will discuss tissue dissociation techniques that lead to high-quality sequencing results.
A closeup of a dead frog floating in water with aquatic plants underneath it
Chytrid Fungus Deploys Varying Strategies to Infect Amphibians
Tess Joosse | Nov 14, 2022 | 2 min read
The ability to activate different sets of genes has likely helped the chytrid fungus Batrachochytrium dendrobatidis spread widely in amphibians, resulting in global population declines. 
Illustration of a human and Neanderthal skull side by side.
Mutation Linked to Difference Between Human and Neanderthal Brains
Dan Robitzski | Sep 9, 2022 | 5 min read
A single amino acid substitution in a protein causes increased neuron production in the frontal lobes of humans compared to Neanderthals—a tiny difference that could have given our species a cognitive edge, researchers say.
Optimizing Reproducibility in Flow Cytometry
Beckman Coulter Life Sciences | 1 min read
Explore real solutions for single cell research.
illustration of brain with DNA strand coming out the top
Genetic Underpinnings of Brain Activity May Differ in Autism
Emily Harris, Spectrum | Jul 19, 2022 | 3 min read
A study finds that expression levels of certain genes that track with brain activity—particularly those involved in brain development—vary between people with autism and their non-autistic peers.
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