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Fast-Acting Nonhormonal Male Birth Control Prevents Pregnancy in Mice
Fast-Acting Nonhormonal Male Birth Control Prevents Pregnancy in Mice
The “on demand” drug immobilizes sperm rather than limit their production, preventing 100 percent of pregnancies in an experiment.
The “on demand” drug immobilizes sperm rather than limit their production, preventing 100 percent of pregnancies in an experiment.
drug design
New Australian Center Will Develop Therapies for Future Pandemics
Shawna Williams | Aug 31, 2022 | 2 min read
Launched with a $172 million philanthropic donation and funds from the state of Victoria, the Melbourne-based research institute aims to construct drug discovery platforms to speed the introduction of new therapies.
Oust the Mouse: A Plan to Reduce Mammal Use in Drug Development
Natalia Mesa, PhD | Mar 15, 2022 | 7 min read
The Scientist spoke to Mount Desert Island Biological Laboratory’s Jim Strickland about the institute’s new MDI Bioscience initiative to perform more drug testing and development in nonmammalian models.
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels
Natalia Mesa, PhD | Mar 2, 2022 | 3 min read
A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.
Return of the Worms
Catherine Offord | Dec 1, 2021 | 10+ min read
Immunologists and parasitologists are working to revive the idea that helminths, and more specifically the molecules they secrete, could help treat allergies and autoimmune disease.
Infographic: How Worms that Reside in the Gut Could Influence Health
Catherine Offord | Dec 1, 2021 | 3 min read
Research in animals and people supports a range of mechanisms by which the parasites affect physiology and immune responses.
Transforming Virology Research with Cryo-EM
The Scientist’s Creative Services Team and Thermo Fisher Scientific | May 11, 2021 | 1 min read
Explore what researchers can do with Cryo-EM
Microscopic Robots Deliver Drugs to the Brain
Asher Jones | Mar 30, 2021 | 5 min read
Researchers turned white blood cells called neutrophils into drug-smuggling “neutrobots,” which penetrated the blood-brain barrier to treat brain cancer in mice.
Promoting Effective Project Teams for Drug Discovery
The Scientist’s Creative Services Team | Dec 30, 2020 | 1 min read
Download this white paper from Collaborative Drug Discovery to explore how modern informatics systems like CDD Vault® can provide a cross-domain platform for storage, analysis, and sharing to promote greater collaboration between drug discovery project team members.
Activities Discovered for Some Inactive Drug Ingredients
Ruth Williams | Jul 23, 2020 | 4 min read
Screens of hundreds of drug excipients reveal that some can interact with biological targets, contradicting their FDA categorization as inert.
Infographic: Building Bacteria to Fight Cancer
Simone Schuerle and Tal Danino | Apr 1, 2020 | 3 min read
Researchers are engineering microbes to deliver therapeutics specifically to tumors, maximizing the treatments’ efficacy while minimizing side effects.
Bacteria as Living Microrobots to Fight Cancer
Simone Schuerle and Tal Danino | Apr 1, 2020 | 10+ min read
Autonomous, living microrobots that seek and destroy cancer are not as futuristic as one might imagine, thanks to a fusion of robotics and synthetic biology.
Amyloid Designed to Inactivate Cancer-Related Protein
Kerry Grens | Nov 13, 2016 | 1 min read
Researchers build a peptide that causes a receptor to form toxic, amyloid-like clumps in cells.
Anticipating Resistance
Jyoti Madhusoodanan | Feb 16, 2015 | 3 min read
Using computational algorithms and experimental evolution, researchers are predicting antimicrobial-resistance patterns to improve drug design.
Chemistry as Art
Abby Olena, PhD | Jan 31, 2014 | 1 min read
See Scientist To Watch Phil Baran describe the artistry of his research in drug discovery.