CRISPR

By editing primary T cells with CRISPR, researchers begin to settle a long-standing debate about a common autoimmunity risk variant.

In a bid to address safety concerns about immune reactions during treatment with CRISPR-based therapeutics, a new technique speeds up how quickly the body destroys the DNA-cutting enzyme Cas9.

Researchers repurpose tiny bacterial injection systems to specifically inject a wide variety of proteins into human cells and living mice.

Benedetta Artegiani and Delilah Hendriks formed a joint laboratory group to understand disease mechanisms and treatments through organoid models.

An engineered methylation pattern persisted for four generations of mice, demonstrating transgenerational epigenetic inheritance can occur in mammals.

A study employing CRISPR/Cas9 to explore the evolutionary beginnings of some giant viruses finds evidence their large genomes arose from gene duplications.

Prairie voles lacking functional receptors for oxytocin form normal social bonds, a finding that could explain the hormone’s clinical failures.

A biotech startup called Tessera Therapeutics has made a splash with its claims about the trademarked technology. Is the excitement justified?

Natural science research projects were among those promised funding by the now-collapsed crypto exchange’s “effective altruism” foundations.

As alternatives to insecticides, Omar Akbari uses sophisticated genetic engineering methods to solve the world’s mosquito problems.

Researchers turned to base editors to correct mutations causing the rare genetic disease Fanconi anemia without inducing double-strand DNA breaks.

Immune defense genes in bacteria and archaea can identify viral proteins, a study finds, revealing similarities between the immune systems of prokaryotic and eukaryotic organisms.

The biotech company Verve Therapeutics launched the study with the aim of using base editing to treat a genetic condition that causes high cholesterol and increases a person's risk of developing cardiovascular disease.